By International Agency for Research on Cancer Staff
Offers re-evaluations of the carcinogenic dangers to people posed through publicity to a few 121 natural compounds, often business chemical substances, chosen from one of the 834 brokers evaluated in volumes 1-70 of the IARC Monographs sequence. chemical compounds have been chosen for re-assessment at the foundation of substantial new proof that may demand a metamorphosis within the IARC category of carcinogenic risk.The reviews are offered in 3 elements. half one presents complete exams of all suitable info on experimental carcinogenesis and melanoma epidemiology for 4 chemical compounds: acrylonitrile 1 3-butadiene, chloroprene, and dichloromethane. of those, 1 3-butadiene remained labeled as most likely carcinogenic to people, and dichloromethane remained categorized as most likely carcinogenic to people. Acrylonitrile, formerly labeled as most likely carcinogenic to people, used to be reclassified as probably carcinogenic. For chloroprene, formerly judged no longer classifiable, new epidemiological facts and new bioassays demonstrating carcinogenicity in rats and mice supported category as in all probability carcinogenic to humans.Part re-evaluates 30 compounds for which new epidemiological or experimental carcinogenicity info have been to be had and for which adjustments in type have been expected. half 3 offers short updates for seventy six compounds and teams of compounds for which new proof used to be constrained to experimental carcinogenicity info. As no new epidemiological proof used to be on hand, and no reclassification used to be expected, those monographs reproduce the former precis reviews and replace those with descriptions of latest information.
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Presents re-evaluations of the carcinogenic dangers to people posed via publicity to a few 121 natural compounds, generally commercial chemical compounds, chosen from one of the 834 brokers evaluated in volumes 1-70 of the IARC Monographs sequence. chemical substances have been chosen for re-examination at the foundation of substantial new facts that would demand a metamorphosis within the IARC category of carcinogenic chance.
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Extra resources for Re-evaluation of Some Organic Chemicals: Hydrazine and Hydrogen Peroxide
Carcinogenesis, 7, 1853–1863 GENERAL REMARKS Since the beginning in 1971 of the IARC Monographs Programme on the Evaluation of the Carcinogenic Risk of Chemicals to Man, now the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, some 834 agents have been evaluated, some of them more than once. These monographs and evaluations were published in Volumes 1–70 of the series. During recent years, the volume of biological data that could be relevant to an evaluation process has increased enormously and there has been growing concern that many of the older evaluations are becoming out of date and may require re-evaluation.
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