By Francis Knowles (auth.), Sir Francis Knowles F.R.S., Lutz Vollrath (eds.)
This quantity marks the tip of 20 years of neurosecretion in which there have been 5 symposia, particularly Naples (1953), Lund (1957), Bristol (1961), Strasbourg (1966), and Kiel (1970). compared to those symposia a very huge variety of papers have been learn at this the 6th symposium, in London, and for financial purposes it has no longer been attainable to submit all of the papers in extenso. The editors have hence been obliged to adopt the unenviable paintings of choice, a job made the entire tougher via the excel lence and value of contributions of the symposium. We felt that it was once of the maximum significance at this second within the historical past of neurosecretion to give as whole an image as attainable of the current nation of the topic on the subject of the prior and possibilities for the longer term. we've for this reason given a few choice to papers with a powerful evaluate point, examine papers in parts of present value and contributions which take care of lately built ideas with promise for the longer term. now we have extra over tried to strike a few stability among the various parts of analysis on neurosecretion in order that the amount as a complete will be of curiosity to the final reader, and that he'll locate in it a pretty coherent development of suggestion which demonstrates neurosecretion because the ultimate neuroendocrine pathway. now we have tried a undeniable measure of uniformity of spelling, symbols, etc.
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Extra info for Neurosecretion — The Final Neuroendocrine Pathway: VI International Symposium on Neurosecretion, London 1973
C: after one week; the pericapillary endings loaded with vasopressin, D: after two months: the hypothalamo-neurohypophysial tract is not visible (PT: pars tuberaIis, HT: hypothalamohypophysial tract, C: portal vessels) 28 A. BURLET et al. : seem totally independent. Fluorescence extends to dendrites of paraventricular neurons oriented toward the ependymal lining of the third ventricle and to dendrites of the SON latero-external zones (Fig. 1). The intra-hypothalamic axonal paths are easily observed (Fig.
Exo-Endocytosis in the Neurohypophysis as Revealed by Freeze-Fracturing J. J. DREIFUSS 1 , J. J. NORDMANN*l, K. AKERT2, C. SANDRI2, and H. MooR 3 Department of Physiology, University of Geneva 1 ; Brain Research Institute, University of Ziirich', and Institute of General Botany, Federal Institute of Technology, Ziirich3 (Switzerland) Evidence has accumulated to indicate that the release of the neurohypophysial hormones occurs by exocytosis (emiocytosis, and reverse pinocytosis, are synonyms). During this process, the secretory granule-limiting membrane fuses with the plasma membrane, and an opening is formed which allows passage of the soluble content of the neurosecretory granules to the extracellular environment.
Encircled arrowheads indicate orientation of shadow casting. Primary magnification 20000 x J. J. 34 Fig. 2A and B (Legend see p. 35) DREIFUSS et aI. : Freeze-Fracture of Neurohypophysis 35 limiting membrane may fuse during exocytosis with the particles located on the plasma membrane. Particles present on fracture faces probably represent protein molecules which penetrate into, or even traverse, the membrane. The particle aggregates seen in neurosecretory granule and plasma membranes thus represent an orderly arrangement of proteins within the lipid matrix of the membrane.