By Arthur Karlin (Eds.)
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T h e clinical implications of these findings are important since they give credence to an older view, which attributed the vulnerability of degenerative diseases of brain, in part, to variations in the number of such neurons. SUMMARY It is evident from the preceding analysis that one macromolecule of importance in the regulation of the transynaptic transfer of information from central catecholamine neurons—the enzyme tyro sine hydroxylase, which catalyzes the first step in catecholamine biosynthesis—is capable of variations in its amount and activity in adult life.