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Alternatively the advances in molecular biology and tumor immunology have made a progress in immunotherapy against malignancy, especially in the field of immunological targeting therapy by use of monoclonal antibodies related to immune checkpoint pathway. It is no exaggeration to say that now is the chance for improving both specific and nonspecific immunotherapy against malignancies. 1 Introduction In spite of considerable improvement in survival rates, prognosis of either advanced stage cancer or recurrent malignancies remains still poor.
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1 Mechanisms of polysaccharides in tumor immunity References 1. Vickers AJ, Kuo J, Cassileth BR (2006) Unconventional anticancer agents: a systematic review of clinical trials. J Clin Oncol 24:136–140 2. Zhang Y, Kong H, Fang Y et al (2013) Schizophyllan: a review on its structure, properties, bioactivities and recent developments. Bioact Carbohydrates Diet Fibre 1(1):53–71 3. Nio Y, Shiraishi T, Tsubono M et al (1991) In vitro immunimodulating effect of protein-bound polysaccharide, PSK on peripheral blood, regional nodes, and spleen lymphocytes in patients with gastric cancer.