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Alternatively the advances in molecular biology and tumor immunology have made a progress in immunotherapy against malignancy, especially in the field of immunological targeting therapy by use of monoclonal antibodies related to immune checkpoint pathway. It is no exaggeration to say that now is the chance for improving both specific and nonspecific immunotherapy against malignancies. 1 Introduction In spite of considerable improvement in survival rates, prognosis of either advanced stage cancer or recurrent malignancies remains still poor.

Clin Dev Immunol 2012:230625. 1155/2012/230625, Epub 2012 Nov 11 21. Klier U, Maletzki C, G€ottmann N, Kreikemeyer B, Linnebacher M (2011) Avitalized bacteria mediate tumor growth control via activation of innate immunity. Cell Immunol 269(2): 120–127. 014, Epub 2011 Mar 17 22. Hobohm U (2005) Fever therapy revisited. Br J Cancer 92(3):421–425 23. Klenk M, Nakata M, Podbielski A, Skupin B, Schroten H, Kreikemeyer B (2007) Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells.

1 Mechanisms of polysaccharides in tumor immunity References 1. Vickers AJ, Kuo J, Cassileth BR (2006) Unconventional anticancer agents: a systematic review of clinical trials. J Clin Oncol 24:136–140 2. Zhang Y, Kong H, Fang Y et al (2013) Schizophyllan: a review on its structure, properties, bioactivities and recent developments. Bioact Carbohydrates Diet Fibre 1(1):53–71 3. Nio Y, Shiraishi T, Tsubono M et al (1991) In vitro immunimodulating effect of protein-bound polysaccharide, PSK on peripheral blood, regional nodes, and spleen lymphocytes in patients with gastric cancer.

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