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By Matthias Reumann

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Additional resources for Computer Assisted Optimisation of Non-Pharmacological Treatment of Congestive Heart Failure and Supraventricular Arrhyth

Sample text

E. they are excited with a certain variable frequency2 . The SA node is setting the heart rate with an average 60 - 80 beats per minute during rest. Thus, its cells are also called primary pacemaker cells. The excitation is spreading across the atria to the atrio - ventricular node (AV node). The excitation propagates through atrial working myocardium. There are no special isolated, fast conducting pathways that explicitly link the SA node and the AV node (see fig. 3). The AV node is an area located in a fibrous triangle in the hearts center between the mitral and tricuspid valve and the aorta.

The remodelling process then continues over a period of month rendering the heart in a hypotrophic state and a more spherical state [140]. 3. Figure A shows the ventricular remodelling process after an apical infarction. The initial infarct will not show clinically significant changes in the geometry. However, within days to month, the area affected becomes thinner and expands ending in global remodelling and dilatation. Figure B shows the remodelling process in classical diastolic and systolic heart failure.

Typical ion concentration and their associated Nernst voltages of sceletal muscle [266]. Goldman-Hodgkin-Katz Equation While the Nernst Equation takes care of only one ion type, the Goldman-Hodgkin-Katz Equation includes principally all ion types. It is an extention of the Nernst Equation where each ion concentration [Ion] is associated with the respective permeability of the membrane PIon which in turn no longer requires the valence number zIon . 10) . 2. Myocardial Cells 25 including the diffusion constant DIon (eq.

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