Download Cocaine Abuse: Behavior, Pharmacology, and Clinical by Stephen T. Higgins PDF

By Stephen T. Higgins

Cocaine abuse is still a big public ailment and contributes to lots of our most annoying social difficulties, together with the unfold of infectious disorder, crime, violence, and neonatal drug publicity. Cocaine abuse effects from a posh interaction of behavioral, pharmacological, and neurobiological determinants. whereas a whole realizing of cocaine abuse is presently past us, major growth has been made in preclinical examine on basic determinants of this illness. those advances are significantly reviewed within the first part of this quantity. very important advances even have been made in characterizing the medical pharmacology of cocaine, and people advances were prolonged to figuring out person vulnerability to cocaine abuse, improvement of potent remedies, and discussions of coverage. these advances are significantly reviewed within the 3rd part of this quantity. participants to the booklet have been chosen due to their prestige as across the world famous leaders of their respective parts of clinical services. additionally, each one is a proponent of the significance of a rigorous, interdisciplinary clinical method of successfully addressing the matter of cocaine abuse. As such, this quantity bargains a coherent, empirically-based conceptual framework for addressing cocaine abuse that has continuity from the elemental examine laboratory during the medical and coverage arenas. all the particular chapters is satisfactorily exact, in-depth and present to be worthwhile to expert readers with particular pursuits whereas additionally delivering a finished assessment when you will be much less expert or have broader pursuits in cocaine abuse. This mix of severe evaluation inside every one bankruptcy with an explicitly conceptual continuity that spans all the chapters makes this quantity a distinct contribution to cocaine abuse particularly and substance abuse as a rule. Key gains* Discusses cocaine abuse in the context of present rules of psychology, pharmacology, neuroscience, genetics and epidemiology* Chapters are all authored via clinical specialists* First of its style publication on cocaine abuse to acknowledge behavioral/environmental determinants* assurance is accomplished* Informative for specialists and generalists alike

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Extra resources for Cocaine Abuse: Behavior, Pharmacology, and Clinical Applications

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The pharmacology of cocaine related to its abuse. Pharmacological Reviews, 41(1), 3-52. 1 6 SARI IZENWASSER Johnson, K. , Bergmann, J. , & Kozikowski, A. P. (1992). Cocaine and dopamine differentially protect [^H]mazindol binding sites from alkylation by A^-ethylmaleimide. European Journal of Pharmacology—Molecular Pharmacology Section, 227, 411-415. Kalivas, P. , & Duffy, P. (1990). Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse, 5, 48-58.

E. A. ), Neurotransmitter transporters: Structure and function. Totowa, NJ: Humana Press Publishers. , & Reith, M. E. A. (1993). Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. Journal of Pharmacology and Experimental Therapeutics, 267, 1445-1453. , & Reith, M. E. A. (1994). Effects of locally applied cocaine, lidocane, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: A microdialysis study on monoamine interrelationships.

FEBS, 257, 341-344. -J. (1994). Cocaine and GBR 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier. European Journal of Pharmacology, 268, 187-197. Schad, C. , Justice, J. , & Holtzman, S. G. (1995). Naloxone reduces the neurochemical and behavioral effects of amphetamine but not those of cocaine. European Journal of Pharmacology, 275, 9-16. , & Langer, S. Z. (1985). Sodium dependent [^H]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinson's disease.

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