Download Carbonic Anhydrases as Biocatalysts: From Theory to Medical by Claudiu T Supuran, Giuseppina De Simone PDF

By Claudiu T Supuran, Giuseppina De Simone

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, current all through such a lot dwelling organisms and encoded by way of 5 evolutionarily unrelated gene households. The Carbonic Anhydrases as Biocatalysts:From conception to clinical and commercial Applications provides details at the becoming curiosity within the research of this enzyme relations and their functions to either medication and biotechnology.

  • Offers finished assurance of the carbonic anhydrases enzyme kin and their houses as biocatalysts
  • Includes present functions of carbonic anhydrases in biotechnology at the foundation in their catalytic potency, together with new applied sciences for CO2 catch processes
  • Identifies new pursuits for drug layout studies
  • Provides a selectivity profile for the several carbonic anhydrases and their comparable biomedical applications

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Swenson ER, Dodgson SJ, Tashian RE, Gros G, Carter ND. Distribution and functions of carbonic anhydrase in the gastrointestinal tract. Carbonic anhydrases: cellular physiology and molecular genetics. New York: Plenum Press; 1991. p. 265–87. 37. Krishnamurthy VM, Kaufman GK, Urbach AR. Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem Rev 2008;108:946–1051. 38. Gao BB, Clermont A, Rook S. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.

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58. Maresca A, Temperini C, Vu H, Pham NB, Poulsen S, Scozzafava A, et al. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J Am Chem Soc 2009;131: 3057–62. 59. Balboni G, Congiu C, Onnis V. Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. Bioorg Med Chem Lett 2012;22:3063–6. 60. Sahin H, Can Z, Yildiz O. Inhibition of carbonic anhydrase isozymes I and II with natural products extracted from plants, mushrooms and honey.

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