By Rajendra Prasad
This ebook on Candida albicans and comparable pathogens presents a well timed review of the groundbreaking discoveries made within the components of drug resistance, host–pathogen interactions, virulence, host immune procedure modulation, etc., within the final decades.
This complete second version contains chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal brokers, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the telephone wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and final yet no longer the least host-immune responses. As such, it deals an incredible reference consultant for mycologists, researchers, pharmacists, clinicians, and undergraduate scholars engaged or drawn to fungal study. it is going to additionally gain clinicians, who're required to maintain abreast of the present kingdom of study on antifungal drug resistance and antifungal development.
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Extra info for Candida albicans: Cellular and Molecular Biology
In Europe, candidemia due to C. albicans and NAC species accounted for 40 and 42% mortality, respectively, across hospitals, and 34 and 28% attributable mortality, respectively, in ICUs 28 R. Singh and A. Chakrabarti (Vincent et al. 2006; Pfaller and Diekema 2007; Todi 2013). 8%, respectively, in the Indian ICUs (Chakrabarti et al. 2015). 2% of device-related infections (Todi 2013). Abdominal candidiasis, especially pancreatitis, is an emerging infection in South Asia. It generally results from the invasion of Candida across gastrointestinal tract mucosa during abdominal surgery or chemotherapy.
Albicans versus NAC species. A study from Thailand reported APACHE II score greater than 15 and central venous catheters, but not, immunocompromised conditions, as the predominant risk factors for acquiring bloodstream infections due to C. albicans compared with NAC species (Apisarnthanarak et al. 2009). 3 Spectrum of Candida Species Historically, C. albicans accounted for 70–80% cases of invasive candidiasis, but the trend has gradually shifted towards NAC species in the past few decades. The shift is much more in South-Asian countries where NAC species were reported in 70–90% of cases (Chakrabarti et al.
Clin Infect Dis 62 (4):15, e1–e50 Pappas PG, Kauffman CA, Andes D et al (2009) Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 48 (5):503–535 Pfaller MA, Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. 5-year analysis of susceptibilities of Candida species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion. J Clin Microbiol 48(4):1366–1377 Pfeiffer CD, Samsa GP, Schell WA et al (2011) Quantitation of Candida CFU in initial positive blood cultures.