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By Jean Dausset (auth.), Prakash Chandra (eds.)

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Lejeune and ]. F. Kearney. Evidence that murine pre-B cells synthesize mu heavy chains but no light chains. Nature, 280:838 (1979). P. L. Preud'homme. lmmunoglobulin expression in human lymphoblastoid cell lines with early B cell features. Scand. ]. , 13:303 (1981). HUMAN LEUKEMIC CELLS OF B LlNEAGE 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. B. L. Preud'homme, M. E. M. D. F. Bollum. Diversity of immunoglobulin expression in leukemic cells resembling B lymphocyte precursors. Nature, 290 :339 (1981).

C. Morvan and J. P. Gras, Polypose rectocolique familiale et syst~me HLA. Apropos d'une observation, Bordeaux Medical 30:2125 (1977). Sasazuki, H. Kaneoka, Y. Nishimura, R. Kaneoka, M. Hayama and H. Ohkuni, An HLA-linked immune suppression gene in man, J. Exp. Med. 152:2:297 (1980). Rosner, E. Cohen, S. G. Gregory, U. Khurana and C. 5). W. J. Ernbleton, MV. A. A. JOnes, C. Holmes and Barbara Gunn Cancer Research Campaign Laboratories University of Nottinghom Nottingham NG7 2RD! K. INTRODUCTION Neoplastic transformation results in the expression in transformed cells of antigens which are not present in their normal cell counterparts, at least in the adult host.

Also antibody localized prefentially in tumour Sp4 when compared with another mammary tumour (Sp15) developing at a contralateral site. 0 ;::: 0> (,) < c ~ .... -. 5 §.... VI ... "" ;;: .... i ~ :::I 0 :: '" CI<: :::I .... ==:::I § i"" :: ~ > ;::: §.... ""> ::; RAT 2 >~ c ~ ~ .... Z~ ~::::>.... ""~c '" > '" CL: >- Q, RAH Fig. 2. e studies the use cf Sp4/A4 antibody as a carrier for adriamycin in the therapy of Sp4 tumour has been examined (Pimm et al. 1981). In the initial series, adriamycin (Doxorubicin) conjugation to antibody or normal rat IgG was effected through a dextran bridge (Hurwitz et al.

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