Download Advances in Clinical Trial Biostatistics by Nancy L. Geller PDF

By Nancy L. Geller

From points of early trials to advanced modeling difficulties, this beneficial reference summarizes present method utilized in the layout and research of medical trials. Chapters are contributed through the world over respected methodologists skilled in medical trials perform.

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1995). An extension of the continual reassessment methods using a preliminary up-and-down design in a dose finding study in cancer patients, in order to investigate a greater range of doses. Statistics in Medicine 14: 911– 923. National Cancer Institute (1993). Investigator’s handbook: A manual for participants in clinical trials of investigational agents sponsored by the Division of Cancer Treatment, National Cancer Institute. Newell, D. R. (1994). Pharmacologically based phase I trials in cancer chemotherapy.

Statistics in Medicine 14: 911– 923. National Cancer Institute (1993). Investigator’s handbook: A manual for participants in clinical trials of investigational agents sponsored by the Division of Cancer Treatment, National Cancer Institute. Newell, D. R. (1994). Pharmacologically based phase I trials in cancer chemotherapy. Hematology Oncology Clinics of North America 8:257–275. , Fisher, L. (1990). Continual reassessment method: A practical design for phase I clinical trials in cancer. Biometrics 46:33–48.

C. (1997). Accelerated titration designs for phase I clinical trials in oncology. Journal of the National Cancer Institute 89:1138–1147. Storer, B. (1989). Design and analysis of phase I clinical trials. Biometrics 45:925– 937. Thall, P. , Simon, R. , Estey, E. H. (1996). New statistical strategy for monitoring safety and efficacy in single-arm clinical trials. Journal of Clinical Oncology 14:29. Thall, P. , Russell, K. E. (1998). A strategy for dose-finding and safety monitoring based on efficacy and adverse outcomes in phase I/II clinical trials.

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